منابع مشابه
P48 - Leptin, IL4, INFγ in obese asthmatic children
Patients and method 50 atopic asthmatic children; (25 obese and 25 non obese), and 20 controls were involved in the study. Asthmatic children were with different clinical disease stages according to GINA. BMI was determined and peripheral blood samples were taken to determine IFNg, IL-4, and Leptin concentrations. Disease severity was assessed by asthma symptom score and its relation to other p...
متن کاملInsights into eukaryotic primer synthesis from structures of the p48 subunit of human DNA primase.
DNA replication in all organisms requires polymerases to synthesize copies of the genome. DNA polymerases are unable to function on a bare template and require a primer. Primases are crucial RNA polymerases that perform the initial de novo synthesis, generating the first 8-10 nucleotides of the primer. Although structures of archaeal and bacterial primases have provided insights into general pr...
متن کاملA Conserved Role for p48 Homologs in Protecting Dopaminergic Neurons from Oxidative Stress
Parkinson's disease (PD) is the most common neurodegenerative movement disorder characterized by the progressive loss of dopaminergic (DA) neurons. Both environmental and genetic factors are thought to contribute to the pathogenesis of PD. Although several genes linked to rare familial PD have been identified, endogenous risk factors for sporadic PD, which account for the majority of PD cases, ...
متن کاملThe interferon-inducible murine p48 (ISGF3g) gene is regulated by protooncogene c-myc (transcriptionycell growthycytotoxic drugsyresistance)
p48 protein is an integral component of the multimeric interferon (IFN)-regulated transcription factor, ISGF3. We have shown earlier that this gene is regulated by a novel IFN-g-regulated element. In addition to the IFNregulated element, a myc–max binding site is also present in this promoter. In this investigation we have studied the role of this site in the regulation of the p48 gene. In seru...
متن کاملp/CAF modulates the activity of the transcription factor p48/Ptf1a involved in pancreatic acinar differentiation.
p48, also called Ptf1a (pancreas-specific transcription factor 1a), is a tissue-restricted bHLH (basic helix loop helix) transcription factor which is critical for pancreatic commitment during development and for the activation and maintenance of the acinar differentiation programme in the exocrine pancreas. High-level expression of exocrine digestive enzymes, a hallmark of mature acinar cells,...
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ژورنال
عنوان ژورنال: European Journal of Cancer Supplements
سال: 2015
ISSN: 1359-6349
DOI: 10.1016/j.ejcsup.2015.08.099